Structure of a Heterotetrameric Geranyl Pyrophosphate Synthase from Mint (Mentha piperita) Reveals Intersubunit Regulation[W][OA]

摘要

This work presents the crystal structure of mint heteromeric prenyltransferase, which is responsible for the biosynthesis of geranyl pyrophosphate, a precursor of the monoterpene menthol. By combining biochemical and genetic complementation approaches, the authors show that the molecular mechanism regulating specific product formation is mediated by protein–protein interactions.